5-hydroxymethylcytosine(English)

• a modified DNA base that is derived from cytosine and plays an important role in epigenetics and gene regulation. It is the first oxidized product of 5-methylcytosine (5mC), created by the action of TET enzymes
• DOT1L, EZH2, FH, HDAC, HDACi, HOXA9, HSC, JARID2, JmjC, IDH1, IDH2, MM, MDS, MLL, MPN, MEIS1, NPM1, PRC2, SDH, TCA, TET, α-KG, 2-HG, AML, ASXL1, AZA, CMML, DAC, 5mC, DNMT3A, DNMTi
• Epigenetics, Oncology, Translational research, Enzymes
• https://doi.org…rsl.2014.04.012