VHL protein

Von Hippel-Lindau protein (English)

  • a component of the E3 ubiquitin ligase complex, which leads to the polyubiquitination and subsequent proteasomal degradation of the a subunit. HIF-1a is also hydroxylated by factor inhibiting HIF (FIH) at a C-terminal transcriptional activation domain asparagine residue
  • FIH, HIF, PHD, pVHL
  • Proteins, Transcription
  • https://doi.org/10.1113/JP280572