tissue inhibitor of metalloproteinase 2(English)

• a unique member of the TIMP family as, in addition to inhibiting MMPs, it selectively interacts with membrane type 1-MMP (MT1-MMP) at the cell surface, which ultimately leads to the activation of the bound pro-MMP-2 molecule.Loss- and gain-of-function analysis reveals its crucial role in cardiac ECM remodeling. Also denoted as TIMP-2
• MMP, TIMP, ECM, ADAMTS, AVC, BDM, DMSO, HA, LA, LV, TGF-ß
• Cardiology, Molecular biology, Biophysics, Experimental animal
• https://doi.org…mcc.2009.09.013
• https://doi.org…1242/dev.202310