left ventricular outflow tract obstruction(English)

• defined by septal thickness ≥15 mm and a resting LVOT pressure gradient ≥30 mmHg. Exacerbates the hyperdynamic contraction through the Anrep effect, worsening diastolic dysfunction and increasing myocardial energy demands, which collectively raise the risk of heart failure and sudden cardiac death. Anatomic remodeling caused by hypercontractility in HCM resulting from increased myofilament calcium sensitivity
• HCM, OFT, LVOT, CMR, LGE, LVM, LVOTS, P/LP, PDSR, PGS, RVOTO, SARC-NEG, SARC-P/LP, SARC-VUS, UMAP, ANT, ATP, BN-PAGE, CK, DCF, DNFB, H2O2, KI, LV, mCAT-OE, MS, Mt-CK, PCr, ROS, WO, WT
• Cardiology, Hemodynamics, Calcium, Genomics, Pathology, Mitochondrion
• https://doi.org…LURE.120.008006
• https://doi.org…LURE.117.004133
• https://doi.org…CGEN.123.004200
• https://doi.org…rheartj/ehab368
• https://doi.org…NAHA.125.074120