central supramolecular activation cluster(English)

• this inner circle concentrates most of the TCR and CD28, and it is surrounded by the pSMAC that is formed by integrins. The most external ring or distal SMAC is where proteins with large ectodomains are located, such as CD43 and CD45, far from the cSMAC. This typical concentric pattern is not found in the immunological synapses formed with the APCs of dendritic cells
• dSMAC, APC, IS, pSMAC, TCR
• Immunology
• https://doi.org…67.2011.03458.x