cyclic guanosine monophosphate–adenosine monophosphate synthase(English)

• a universal sensor of dsDNA, and a well-established function in infections is the recognition of foreign DNA linked to the orchestration of host defense programs. Also participates in various noninfectious contexts, including antitumor immunity, cellular senescence, and inflammatory diseases; aka MB21D1 or cyclic GMP-AMP synthase
• AMP, dsRNA, GMP, APP, cGMP, IRF, LPS, MBL, MIS-C, MyD88, NF-kB, PASC, PGN, PTX3, RIG-I, SAP, SP-A, SP-D, ssRNA, STING, TLR, TRIF
• Aging, Immunology, Atherosclerosis /atherogenic
• https://doi.org…science.aat8657
• https://doi.org…6/NEJMra2206346