classically activated macrophage(English)

• stimulated with TNF-a, IL-12, and IFN-γ, typically referred to as Th1 cytokines, will generate reactive nitrogen species including nitric oxide (NO) and its derivatives NO2, HNO2 and ONOO–, via the action of inducible nitric oxide synthase. By contrast, macrophage exposure to IL-4, IL-13 and IL-21, classically representing Th2 cytokines, stimulates transcription of arginase and the subsequent generation of polyamines via l-ornithine, which support parasite growth and replication. These are considered as alternatively activated macrophages
• AAMF, iNOS, NO
• Immunology, Parasitology
• https://doi.org…coi.2007.07.002