There are multiple definitions:
combined annotation dependent depletion(English)
- a framework that integrates multiple annotations into one metric by contrasting variants that survived natural selection with simulated mutations
- SNV, HEY2
- Genomics, Scoring systems/scales
- https://cadd.gs…hington.edu/snv
computer-aided drug design(English)
- has been credited to the modern patterns in compound characterization in drug discovery following its inception in 1981. It represents an advancement when compared to HTS as it requires minimal compound design or prior knowledge, but can yield multiple hit compounds among which promising candidates have been elected. Its typical role in drug discovery is to screen out large compound libraries into smaller clusters of predicted active compounds, enabling optimization of lead compounds by improving the biological properties (like affinity and ADMET) and building chemotypes from a nucleating site by combining fragments with optimized function
- ADMET, HTS
- Computing (biomedical), Pharmacology / pharmaceutics
- https://doi.org…02220-7.00005-3
continuous ambulatory drug delivery(English)
- for example a pump to deliver opioid agonist treatment in an acute care setting
- Pharmacology / pharmaceutics, Therapeutic approaches, Anesthesiology/analgesia
- https://doi.org…954-023-00813-x