vesicular acetylcholine transporter(English)
- this specific transporter mediates the transfer of ACh from the cytoplasm into synaptic vesicles. It is an antiporter that couples ACh entry into the vesicle with proton efflux, the same mechanism used for the accumulation of other biogenic amine neurotransmitters. The availability of extracellular Ca2+ is a major determinant in the release of ACh. Upon depolarization of a neuron, Ca2+ enters the presynaptic terminal and facilitates the fusion of the vesicle membrane with the plasma membrane. ACh is then released into the synaptic cleft via exocytosis. Vesamicol is an agent that selectively inhibits this transporter
- ACh, BoNT, MEPP
- Signal transduction, Calcium, Synapse
- https://doi.org…74947-5.00013-4