tau-tubulin kinase 1(English)

• a CNS-specific kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer’s disease and frontotemporal dementia. Is a challenging therapeutic target because it shares a highly conserved catalytic domain with its homolog, TTBK2, a ubiquitously expressed kinase genetically linked to spinocerebellar ataxia type 11
• AD, CNS, FTD, SNP
• Dementia
• https://doi.org…571-020-00875-6