T cell receptor excision circles(English)

• small ring-shaped DNA fragments that are produced as waste products during somatic recombination of the T cell receptor gene locus upon T cell maturation in the thymus. In healthy infants, these fragments are produced in large numbers, whereas in infants with SCID or severe T cell lymphopenia they are either not or only barely detectable. Similarly, KRECs develop during the maturation and somatic recombination of the B cell receptor locus, and their copy number correlates with the number of freshly formed naïve B cells
• DBS, KREC, NBS, PID, SCID, CID, GA, HSCT, IgG, MHC
• Immunology, Neonatology, Screening, Thymus
• https://doi.org…/smw.2020.20254