testicular germ cell tumor(English)
- represents the most common solid malignancy in young men, and is a model for curable cancer due to exquisite chemosensitivity and incorporation of multimodal therapy. Divided broadly into seminoma and nonseminoma (NSGCT) as these distinctions inform management decisions, treatment options, and prognosis. Ability to predict metastases in early-stage disease and responders to chemotherapy in advanced disease is limited. Treatment options for cisplatin-resistant disease are sparse. Adult types are characterized by frequent chromosomal anomalies and low rates of somatic mutations. Large scale integrated molecular analysis of early-stage patients is underway. The role of epigenetics in TGCT development and prognosis is also characterized
- ITGCN, NSGCT, CPH, PANCAN, TCGA
- Andrology, Oncology, Epigenetics, Genetics, Transcription, Biotechnology
- https://doi.org…000000000000347
- https://doi.org…86.2019.1679585
- https://doi.org…sbj.2022.01.004