transferrin receptor protein 1(English)

• promotes uptake of iron into cardiomyocytes (for ATP production) and erythroblasts (for erythropoiesis). Enhances the transmembrane electron transport needed for sirtuin-1 upregulation. knockout leads to mitochondrial dysfunction, downregulation of cardiac autophagy proteins and cardiomyopathy, which can be prevented by sirtuin-1 activation. It provides NAD+, which is needed for sirtuin activation and mitochondrial health
• IST1, KYAT1, L-FABP, MMRM, MYDGF, NHE3, OTUB1, Pp2a, RBP2, SGLT2i, SNCA, TBCA, TFF1, TfR1, UMOD, UMtCK, UROD, ACYP1, ATP, ATPIFI, CA2, CCL5, CCL28, CDHR2, CELSR2, CgA, CST1, DNAJB1, DNAJC9, eGFR, EPCAM, EPO, ERMAP, ESCRT-III, FABP5, FABP6, FDRq, HSPA8, H-FABP, IGBP1, IGF1, IGFBP-1
• Cardiology, Mitochondrion, Erythrocyte
• https://doi.org…acc.2024.07.013