serine/arginine protein kinase 3(English)

• promotes phosphorylation of SRSF1 (serine/argininie-rich splicing factor 1) and thereby drives alternative splicing of TPM1 (tropomyosin 1), favoring exclusion of exon 9a and increased expression of the TPM1b isoform. This isoform shift is observed in HFpEF tissue
• SRDF1, ASO, ECM, HFpEF, LVEDP, RBM20, TPM1, TTN
• Cardiology, Molecular biology, Pathology
• https://doi.org…NAHA.126.081379