peripheral supramolecular activation cluster(English)

• the immunological synapse is the region of contact between a T-cell and an antigen-presenting cell (APC), consisting of a central supramolecular activation cluster (cSMAC) and a peripheral cluster. It was shown that when a naive T cell first encounters an APC presenting the antigen for which it is specific, the immature synapse that first forms contains adhesion molecules in the cSMAC and T-cell receptor (TCR) signalling molecules in the pSMAC. This pattern then reverses as the mature synapse forms so that signal transduction occurs in the cSMAC
• cSMAC, APC, IS, TCR
• Immunology
• https://doi.org/10.1038/nri1420