There are multiple definitions:
loss of heterozygosity(English)
- represents the loss of one allele of a gene at a specific locus, and which frequently involves tumor suppressor genes. Common sites for LOH in gastrointestinal malignancies include 5q (APC), 17p (TP53), and 18p (DPC4/SMAD4). CIN tumors can also have chromosomal abnormalities that lead to gene amplifications, commonly of growth-promoting cellular proto-oncogenes such as the EGF receptor or cyclin D1. This represents another mechanism whereby CIN can promote cell transformation and tumor growth. There are multiple mechanisms that can result in CIN in gastrointestinal cancers including defects associated with chromosomal segregation, the DNA damage response pathway, and telomere stability
- FHIT, CIN, APC, FIGO, GCIG, NCDB, NEC, NECC, NEN, NSE
- Genetics, Gastroenterology, Oncology
- https://doi.org…0432-009-0751-9
- https://doi.org…09954-4.00066-9
- https://doi.org…2885-018-4447-x
late onset hypogonadism(English)
- a condition in older men characterized by measurably low testosterone levels and clinical symptoms mostly of a sexual nature, including decreased desire for sex, fewer spontaneous erections, and erectile dysfunction; aka TDS
- ED, TDS
- Andrology, Aging
- https://doi.org….1159/000520135