individualized knowledge graph(English)

• integrates multiomic and clinical data to create patient-specific metabolic networks, enabling simulation of how microbial perturbations - such as depletion of Akkermansia - alter lipid trafficking, increase TMAO production, and promote endothelial dysfunction
• CAD, CLA, FXR, GLUT4, GPR, HDAC, HFmrEF, HFpEF, HFrEF, IEC, LDL, LPS, LPCAT3, LVEF, MAPK, MetS-HF, PI3K, PPAR, PUFA, SCFA, T2DM, TGR5, TLR4, TMA, TMAO, AMPK
• Artificial intelligence, Personalized approach, Patient-centered (interest group), Metabolism, Cardiology
• https://doi.org…eart.00482.2025