unrelated donor bone marrow transplantation(English)

• the use of HLA matched or one antigen mismatched unrelated donors allows successful marrow transplantation in approximately 30% of CML cases where a suitably matched related donor is not available. Unrelated donor marrow transplantation can provide stable engraftment in the majority of recipients and lead to leukemia-free survival in many cases. The beneficial effects of this type of transplantation are particularly apparent in young, chronic phase recipients and when performed using donor/recipient pairs identical at the HLA A, B and DR loci. A higher incidence of graft failure and GVHD than observed in sibling marrow transplant as well as prolonged convalescence in some cases can be anticipated
• CML, GVHD, HLA
• Transplantation
• https://doi.org…428199309047888