steroid 5 alpha-reductase 2(English)

• this gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias
• 5α-RD, AIS, AR, DHT, DSD, CAIS, MAIS, PAIS, PPSH, TT/DHT
• Genetics, Endocrinology, Andrology, Prostate
• https://www.ncb…h.gov/gene/6716
• https://doi.org….2022.2021-9-19