NET

There are multiple definitions:

  1. neutrophil extracellular trap(English)

  2. norepinephrine [reuptake] transporter(English)

  3. neuroendocrine tumor(English)

    • represents a heterogeneous group of malignancies arising in the diffuse neuroendocrine system and characterized by indolent growth. Primary NETs can arise from neuroendocrine cells at various anatomic sites. They most commonly develop in the gastrointestinal tract and bronchopulmonary system. NETs can be classified as functional or non-functional, based on whether they cause clinical symptoms as a result of hormone secretion or not. NET cells overexpress a plethora of proangiogenic molecules including VEGF, PDGF, fibroblast growth factor, semaphorins, and angiopoietins that promote both recruitment and proliferation of endothelial cell precursors, thus resulting among the most vascularized cancers with a microvessel density 10-fold higher than epithelial tumors. Also, NETs operate multifaceted interactions with stromal cells, both at local and distant sites. Their paracrine secretion of serotonin, connective tissue growth factor, and transforming growth factor ß primarily drives the fibroblast activation to enhance the tumor proliferation. Also, NET-derived profibrotic factors accelerate the extracellular matrix remodeling and contribute to heart valves and/or mesenteric fibrosis development
    • FGF, GEP, PDGF, VEGF, pNET, L-NET, SSTR, FIGO, GCIG, NCDB, NEC, NECC, NEN, NSE, SI-NET, GI-NET, ENETS
    • Oncology, Gastroenterology, Pulmonology, Endocrinology
    • https://doi.org…1530/EC-19-0206
    • https://doi.org….1159/000497355
    • https://doi.org…2885-018-4447-x
    • https://doi.org….1159/000512089

  4. narrative exposure therapy(English)