There are multiple definitions:

1. medication-overuse headache(English)

   • usually occurs when painkillers are taken frequently to relieve headaches. It is one of the most common chronic headache disorders and a public health problem with a worldwide prevalence of 1–2%
   • CGRP, OTC
   • Headache, Public Health
   • https://doi.org…042098614522683

2. Ministry of Health(English)

   • CKD, GFR, rhuEPO
   • Kidney and adrenals, Erythrocyte
   • http://pubmed.n…h.gov/17237894/