There are multiple definitions:

1. isocitrate dehydrogenase(English)

   • drives tumor progression by producing an oncometabolite, D-2-hydroxyglutarate (D-2HG), which is a competitive inhibitor of α-ketoglutarate
   • CNS tumor, KDM5C, KDM6A, JARID, UTX, TCGA, CNS, TERT
   • Oncology, Neuropathy
   • https://doi.org…2276-019-0230-6
   • https://org/doi…6/NEJMoa2304194
   • https://doi.org…47/CMAR.S244262
   • https://doi.org…cancers15205094

2. intradialytic hypotension(English)

   • Hemodynamics, Nephrology