human respiratory syncytial virus(English)

• the leading viral agent of serious pediatric respiratory disease worldwide. Also responsible for substantial morbidity and mortality in the elderly and in severely immunocompromised individuals. HRSV is an enveloped nonsegmented negative-strand RNA virus. The genome is approximately 15.2 kb in length. It is tightly wrapped in a nucleocapsid containing a virally encoded polymerase, and is transcribed by a sequential stop–start mechanism into 10 mRNAs encoding 11 proteins. Viral transcription and RNA replication occur in the cytoplasm and the virus buds at the plasma membrane. HRSV is unusual in its ability to infect very early in life, with the peak of serious disease at 1–2 months of age. Reinfection throughout life is common, although mostly the very young and the very old experience serious disease. HRSV occurs in yearly epidemics. Neither a vaccine nor a highly effective specific therapy is available. Infants at high risk for serious disease, due to prematurity or underlying pulmonary or cardiac illness, can be substantially protected by passive immunoprophylaxis with a commercially available virus-neutralizing antibody
• mRNA, RNA, RSV
• Virology, Pediatrics, Neonatology, Epidemiology, Transcription
• https://doi.org…74410-4.00487-8