FIR

There are multiple definitions:

  1. finite impulse response(English)

  2. FBP Interacting Repressor(English)

    • FBP binds to FUSE. A molecular machine composed of FUSE, FBP, FIR, and TFIIH integrates multiple inputs to set the output of the proto-oncogene. Upon c-myc activation, SWI/SNF displaces a FUSE-masking nucleosome; with the onset of transcription, incipient torsional strain melts FUSE, allowing FBP to bind the “bottom” strand of FUSE, presumably through all 4 of the protein's KH domains, and then activate transcription through TFIIH. Next, FIR, recruited by FBP-FUSE, represses transcription, delimiting the pulse of c-myc expression. Declining supercoiling rapidly releases FBP from binding with FUSE, but FIR dissociates much more slowly
    • FBP, FUSE, KH, SNF, ssDNA, SWI
    • Oncology, Transcription
    • https://doi.org…pnas.0803279105
  3. face identity recognition(English)

  4. flow increase rate(English)