fibrillary glomerulonephritis(English)

• rare disorder comprising 0.6–1.5% of native kidney biopsies, manifesting with proteinuria, hematuria, and hypertension with progression to end-stage renal disease occurring within the course of months to a few years, and characterized by the deposition of fibrillary structures in glomeruli that range from 16 to 24 nm in diameter. Immunofluorescence usually shows bright diffuse glomerular staining for IgG and C3, with more variable and weaker positivity for other immunoglobulins. By definition, the fibrils are Congo red or thioflavin T negative, a biochemical characteristic that distinguishes them from amyloid fibrils
• MPGN, ESRD, IF, IgG, MGFD
• Nephrology
• https://doi.org…038/ki.2008.577