drug-induced liver injury(English)

• an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use. Drugs can be harmful to the liver in susceptible individuals owing to genetic and environmental risk factors. These risk factors modify hepatic metabolism and excretion of the DILI-causative agent leading to cellular stress, cell death, activation of an adaptive immune response and a failure to adapt, with progression to overt liver injury
• DLST, DIALF, MAPK, G6PC
• Liver disease, Injury, Adverse effect, Genetics, Environment, Immunology
• https://doi.org…1572-019-0105-0
• https://doi.org…9/acm.2009.0183