delayed gadolinium-enhanced magnetic resonance imaging of cartilage(English)
- technique is based on the fact that glycosaminoglycans contain negatively charged side chains, which lead to an inverse distribution of negatively charged contrast agent molecules (such as gadolinium) with respect to glycosaminoglycans concentration. As the concentration of Gd-DTPA2- molecules can be approximated by measuring T1, T1 mapping of cartilage after intravenous administration of Gd-DTPA2- allows a quantitative assessment of glycosaminoglycan content. The T1 measurement after penetration of Gd-DTPA2- is referred to as the dGEMRIC index. Areas of cartilage with a lower dGEMRIC index are commonly observed in joints in which radiographic findings are indicative of OA
- OA, JSN, KOA, MRI, CAL, PC
- Shoulder and other joints, Medical imaging
- https://doi.org/10.1186/ar3488
- https://doi.org…hro.2017.10.023