D-amino acid oxidase(English)

• several NMDAR-enhancing agents, especially those that function through the glycine modulatory site (GMS) of NMDAR, cause significant reduction in psychotic and cognitive symptoms in patients with schizophrenia. Given that the NMDAR-mediated signaling pathway has been implicated in cognitive/social functions and that GMS is a potential therapeutic target for enhancing the activation of NMDARs, there is great interest in investigating the effects of direct and indirect GMS modulators and their therapeutic potential, including D-amino acid oxidase inhibitors
• GlyT1, GMS, NMDA, QOL
• Psychiatry, Pharmacology / pharmaceutics
• https://doi.org…syt.2021.742058