antithrombin III(English)
- is a small glycoprotein anticoagulant that inactivates several enzymes of the coagulation system and accounts for most of the antithrombin activity in plasma and also inhibits other proteolytic enzymes. It circulates in the plasma and inactivates thrombin. Hereditary or acquired antithrombin III deficiency results in thromboembolism. It is used to treat congenital antithrombin deficiency, which is of two types. In type I deficiency there are reductions in both antithrombin activity and antithrombin concentration in the blood; in type II deficiency antithrombin concentration is normal but antithrombin activity is reduced. The effectiveness of treatment with antithrombin III, prepared as a concentrate from human plasma, is still a matter of dispute. Apart from vasodilatation, leading to a reduction in blood pressure, remarkably few adverse effects have been noted. The fall in blood pressure seems to be related to the rate of the infusion. High doses of antithrombin III, given to patients with severe sepsis, increased the risk of hemorrhage, particularly when it was given concomitantly with heparin, while there was no treatment benefit; also as AT-III, AT III, or AT
- AT
- Thrombocyte /thrombosis, Sepsis, Emergency medicine
- https://doi.org…53717-1.00020-2
- https://doi.org…02212-1.50014-7