androgen-excessive polycystic ovary syndrome(English)

• females affected experience significant relative hyperandrogenism, and such a model may provide insight into the effects of testosterone administration in trans-men. The supraphysiological levels of testosterone in AE-PCOS have been demonstrated to be responsible for impaired endothelin-1 mediated vasodilation in response to agonists, due to suppression of endothelin B receptor stimulated NO synthesis consequential of androgen binding
• LGBTQ+, AAA, ADMA, AR, BRFSS, CVD, DHT, eNOS, ER, ERß, GPER, LGBTQ, MMP, NHE3, NHR, PCOS, RAAS
• Gender aspects, Ovary and uterus, Hormone
• https://doi.org…sis.2023.117282