acylphosphatase-1(English)
- enhances activity of renal tubular Na+-K+-ATPase. It also hydrolyzes the phosphoenzyme intermediate of SERCA2a, displacing phospholamdan, thus enhancing activity of sarcoplasmic reticulum Ca2+ pump. Promotes sodium reabsorption as a counterregulatory response to the action of SGLT2 inhibitors in the proximal renal tubule. Effect of ACYP1 on SERCA2a leads to enhanced cardiac contractility
- CCL28, CDHR2, CELSR2, CgA, CST1, DNAJB1, DNAJC9, eGFR, EpCAM, EPO, ERMAP, ESCRT-III, FABP5, FABP6, FDRq, HSPA8, H-FABP, IGBP1, IGF1, IGFBP1, IST1, KYAT1, L-FABP, MMRM, MYDGF, NHE3, OTUB1, Pp2a, RBP2, SERCA2a, SGLT2i, SNCA, TBCA, TFF1, TfR1, UMOD, UMtCK, UROD, ATPIFI, CA2, CCL5
- Cardiology, Pathology, Molecular biology
- https://doi.org…acc.2024.07.013