serum mannose-binding lectin(English)

• the assumption that high serum levels provide protection and low levels risk to diseases was initially documented in 1989, when the defect in opsonization because of MBL deficiency (i.e., low sMBL levels) was recognized as the reason of frequent inexplicable infections in children. Then pediatric population-specific studies started emphasizing the importance of nonspecific innate immunity provided by MBL in the early life, and considered as the substitute for the defense offered by the adaptive immunity. Studies based on adults emphasized its role as a first line of defense against pathogens till the adaptive immunity starts responding
• CLR, MASP, MBL, PAMP, PRR
• Immunology, Infection, Pediatrics
• https://doi.org…5/med-2021-0239