small intestinal neuroendocrine tumor(English)

• represents a heterogeneous group of rare, mutationally silent tumors, but basic research has attempted to unravel the molecular events underlying tumorigenesis. In patients with metastatic SI-NET, the carcinoid syndrome is common, which is characterized by diarrhea, episodic flushing, bronchospasm and often carcinoid heart disease leading to right valvular dysfunction. Loss of heterozygosity at chromosome 18 is the most frequent genomic aberration (44–100%) followed by mutations of CDKN1B in 8%. Prognostic analyses found a significant (epi)genetic association for survival or progression. No biomarkers have been identified yet that can easily be adopted into current clinical decision making
• NET, MEN
• Oncology, Epigenetics, Gastroenterology
• https://doi.org…1530/EC-19-0206