myeloid-derived suppressor cell(English)

• member of a heterogeneous population of cells of myeloid origin. These cells expand during various pathological conditions, including cancer, inflammation and trauma, and are characterized by the increased production of reactive oxygen and nitrogen species, and by arginase 1 activity. Two subsets have been identified based on their morphology and cell-surface expression of specific molecules. The granulocytic subset has a CD11b+LY6G+LY6Clow phenotype and the monocytic subset has a CD11b+LY6G−LY6Chi phenotype. Although both subsets can suppress T cells, their mechanisms of suppression are different. Immunosuppressive functions require direct cell–cell contact and can result in antigen-specific or antigen-non-specific suppression of T-cell responses
• Dkk1, G-MDSC
• Immunology, Oncology
• https://doi.org/10.1038/nri2506
• https://doi.org…84/jem.20150950
• https://doi.org…ncotarget.12278