mannose-binding lectin 2(English)

• humans have two MBL genes, of which MBL1 is a pseudogene, leaving MBL2 as the only functional gene that encodes for MBL protein. It comprises 7,461 bases, between 5,27,65,380 and 5,27,72,841 bp region of chromosome no. 10 (10q11.2-q21) (NC_000010.11, NCBI), translating into MBL protein of 248 amino acid (NCBI accession number XP_011538118.1) via a 3,570 bp long mRNA (NCBI accession number NM_000242.21). The gene structure is same as that of other eukaryotic genes with each element contributing to the specific function in gene expression. MBL2 comprises four exons and three introns. The exons determine the structure of proteins with exon 1 encoding signal peptide, a cysteine-rich domain, and a portion of glycine-rich collagenous region. Exon 2 encodes the other portion of the collagenous domain, whereas α-helical “neck” region and CRD are encoded by exons 3 and 4, respectively. In addition, its promoter and 3′UTR region contain various elements that regulate its expression
• CRD, MBL
• Immunology
• https://doi.org…5/med-2021-0239