Kelch-like epichlorohydrin-associated protein 1(English)

• provides a unique sensor system by exploiting multiple reactive cysteine residues, which make KEAP1 possible to handle a variety of electrophilic stresses. For instance, KEAP1 senses electrophiles through cysteine residue Cys151 in the BTB domain and Cys273/288 in IVR. Intriguingly, Cys151 binds diethyl maleate, tert-butylhydroquinone, SFN, and dimethyl fumarate,45 whereas Cys273/288 binds 15-deoxy-Δ12,14-prostaglandin J2 and nitro-fatty acids. Thus, KEAP1 equips multiple sensor functions based on multiple cysteine residues
• luc, mRNA, Neh2, NEM, NO, NQO1, Nrf2, PDB, ROS, SN2, tBHQ, Tg, UGT1A1, WT, COVID-19, ECH, mTOR, NRF2, ROS, BTB, SFN, ARE, CLR, CUL3, DTNB, EPA, FLAG, GSH, GSSG, HA, HMWK, HRP, IAB, Keap1
• Allergy, Transcription, Regulation / control
• https://doi.org…601-020-00362-7
• https://doi.org…med.2015.06.006
• https://doi.org…9/ars.2010.3273