growth hormone-insulin like growth factor-1(English)

• IGF-1 is a member of a family that is involved in growth, development, cell differentiation, and metabolism. IGF1, IGF2 and insulin act primarily through tyrosine-kinase-linked receptors—the IGF1 receptor (IGF1R) and insulin receptor (IR). Upon binding to the receptors, cascades of tyrosine and serine kinases are stimulated to facilitate growth or metabolism. The IGF2 receptor is a scavenger receptor, and therefore not involved in mediation of growth or metabolic effects of the IGF family. IGF1 is a major gene target of growth hormone and its product mediates many of the actions of growth hormone on growth and development; however, IGF1 has actions distinct from those of growth hormone in carbohydrate, lipid, and protein metabolism
• IGF-1, IR
• Hormone, Insulin, Metabolism
• https://doi.org…8/ncpendmet0427